Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Avenue Mounier 73, Box B1.73.11, B-1200 Brussels, Belgium.
Br J Nutr. 2013 Jan;109 Suppl 2:S81-5. doi: 10.1017/S0007114512004047.
Experimental data in animals, but also observational studies in obese patients, suggest that the composition of the gut microbiota differs in obese v. lean individuals, in diabetic v. non-diabetic patients or in patients presenting other diseases associated with obesity or nutritional dysbalance, such as non-alcoholic steatohepatitis. In the present review, we will describe how changes in the gut microbiota composition and/or activity by dietary fibres with prebiotic properties, can modulate host gene expression and metabolism. We will evaluate their potential relevance in the management of obesity and related metabolic disturbances, in view of the experimental data and intervention studies published up to date.
动物实验数据以及肥胖患者的观察性研究表明，肥胖个体与瘦个体、糖尿病患者与非糖尿病患者、或患有与肥胖或营养失衡相关疾病（如非酒精性脂肪性肝炎）的患者相比，其肠道微生物组的组成存在差异。在本综述中，我们将描述具有益生元特性的膳食纤维如何通过改变肠道微生物组的组成和/或活性来调节宿主基因表达和代谢。鉴于迄今为止发表的实验数据和干预研究，我们将评估它们在肥胖及相关代谢紊乱管理方面的潜在相关性。
