Vocational and Technical School, Shenyang Pharmaceutical University, No.11-1, Beiyi Western Road, Tiexi District, Shenyang, 110026, China.
J Nat Med. 2013 Oct;67(4):844-9. doi: 10.1007/s11418-013-0744-5. Epub 2013 Jan 30.
The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4-9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2 μM).
从海南巴戟根的甲醇提取物中分离得到三个新化合物，24,26-二羟基-25-甲氧基-齐墩果-9-烯-3-酮（1）、2β,3β,22α-三羟基-羽扇豆-20(29)-烯（2）和 3β-羟基-2-羰基-羽扇豆烷-29-酸（3），以及六个已知的三萜类化合物（4-9）。根据光谱分析，特别是二维 NMR 和高分辨率质谱实验获得的数据，确定了它们的结构。其中一些化合物对α-葡萄糖苷酶的抑制活性比阳性对照（阿卡波糖，IC₅₀ 10.2 μM）强得多。
