Gao Hui-Yuan, Guo Zheng-Hong, Cheng Peng, Xu Xiao-Min, Wu Li-Jun
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
J Asian Nat Prod Res. 2010 Oct;12(10):834-42. doi: 10.1080/10286020.2010.503653.
Fractionation of the methanol extract from the roots of Salacia hainanensis Chun et How showing the potent inhibitory activity on α-glucosidase afforded two new lupane derivatives, 3α,28-dihydroxy-lup-20(29)-en-2-one (1) and 3α-hydroxy-lup-20(29)-en-2-one (2), a new friedelane derivative, D:A-friedo-oleanane-7α,30-dihydroxy-3-one (3), and a novel natural product, 2,3-seco-lup-20(29)-en-2,3-dioic acid (4), along with four known compounds (5-8). Their structures were established on the basis of spectral analysis, especially on the data afforded by 2D NMR and high-resolution mass spectra experiments. All of them showed a much stronger inhibiting activity on α-glucosidase than the positive control (acarbose, IC₅₀ = 5.83 μM). Constituents with α-glucosidase inhibitory activity from this plant are reported for the first time.
从海南五层龙（Salacia hainanensis Chun et How）根部的甲醇提取物中分离得到具有对α-葡萄糖苷酶强抑制活性的两种新羽扇豆烷衍生物，3α,28-二羟基-羽扇-20(29)-烯-2-酮（1）和3α-羟基-羽扇-20(29)-烯-2-酮（2），一种新的木栓烷衍生物，D:A-去甲-齐墩果烷-7α,30-二羟基-3-酮（3），以及一种新型天然产物，2,3-裂羽扇-20(29)-烯-2,3-二酸（4），同时还有四种已知化合物（5 - 8）。它们的结构是基于光谱分析确定的，特别是二维核磁共振和高分辨质谱实验所提供的数据。所有这些化合物对α-葡萄糖苷酶的抑制活性均比阳性对照（阿卡波糖，IC₅₀ = 5.83 μM）强得多。首次报道了该植物中具有α-葡萄糖苷酶抑制活性的成分。
