Faculty of Pharmacy, Department of Clinical Biochemistry, University of Ljubljana, Askerceva 7, Ljubljana SI-1000, Slovenia.
J Orthop Res. 2013 Jul;31(7):1059-66. doi: 10.1002/jor.22318. Epub 2013 Jan 29.
Several studies have shown that in contrast to osteoporosis (OP), osteoarthritis (OA) is characterized by high bone mineral density (BMD). Bone strength not only depends on mineral content as determined by dual X-ray absorptiometry (DXA), but also on bone microarchitecture. We studied intertrochanteric bone from normal controls and OA and OP patients by bone histomorphometry (BHM) and microcomputed tomography (µCT) as well as DXA in order to first, test the differences between OA and OP comparing both groups to healthy controls, second, to assess variations between three different skeletal sites in controls and third, to determine the level of agreement between µCT, BHM, and DXA. Analysis was performed on 115 samples from OA and OP patients, and controls. We found significant differences between OA and OP samples in structural parameters and in the osteoid fraction (p < 0.05). The majority of the intra-skeletal differences were shown between lumbar spine and femoral head samples (p < 0.05). Significant agreements were found between µCT and BHM and DXA (r = 0.32-0.45, p < 0.05). Our findings suggest differences in intertrochanteric bone between OA and OP, the age-related intra-skeletal variations and a correlation between microscopic and macroscopic bone evaluation methods.
多项研究表明，与骨质疏松症（OP）相反，骨关节炎（OA）的特征是骨矿物质密度（BMD）高。骨强度不仅取决于双能 X 射线吸收法（DXA）测定的矿物质含量，还取决于骨微观结构。我们通过骨组织形态计量学（BHM）和微计算机断层扫描（µCT）以及 DXA 研究了来自正常对照和 OA 和 OP 患者的转子间骨，目的首先是比较 OA 和 OP 组与健康对照组之间的差异，其次是评估对照组三个不同骨骼部位之间的差异，第三是确定 µCT、BHM 和 DXA 之间的一致性水平。对来自 OA 和 OP 患者和对照组的 115 个样本进行了分析。我们发现 OA 和 OP 样本在结构参数和类骨质分数方面存在显著差异（p < 0.05）。大多数骨骼内差异显示在腰椎和股骨头样本之间（p < 0.05）。µCT 和 BHM 与 DXA 之间存在显著相关性（r = 0.32-0.45，p < 0.05）。我们的发现表明 OA 和 OP 之间转子间骨存在差异、与年龄相关的骨骼内变化以及微观和宏观骨评估方法之间的相关性。
