Lv H, Zhang L, Yang F, Li M, Yin P, Su X, Yin P, Zhang L, Tang P
Department of Orthopedics, General Hospital of Chinese PLA, No. 28 Fuxing Road, Beijing, 100853, China.
BNLMS State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Osteoporos Int. 2015 Jun;26(6):1791-9. doi: 10.1007/s00198-015-3058-5. Epub 2015 Feb 24.
In this study, we propose a novel method for accurate trabeculae extraction from human femoral heads using 3D-printing techniques and compare spatial deviation errors between this novel method and the conventional method. We found that spatial deviation errors, which indicate inaccuracy and unreliability, were significantly higher with the conventional method.
Assessment of structural and mechanical properties of local bone is important in the study of pathological changes associated with musculoskeletal degenerative diseases. However, the widely used visual extraction method (VIS) for trabecular columns showed large deviations from veridicality, referred to as spatial deviation errors (SDE). Here, we propose a novel method for accurately locating and trephining trabeculae using a 3D-printed (3DP) positioning device and also evaluate the SDE of the VIS.
Twenty femoral heads were obtained from osteoporotic patients, and the trabecular columns were extracted from the principal compressive trabeculae by VIS (n = 10) or the 3DP (n = 10) method. Morphological, structural, and mechanical properties were compared between both groups along with the recorded errors in spatial deviation.
Compared with the 3DP group, the average angle of central axis deflection in the VIS group was significantly greater; SDE in the VIS group was 26.1, 8.8, 4.1, 9.8, 7.2, 8.1, and 10.1 % greater for bone mineral density, bone volume/tissue volume ratio, trabecular thickness, trabecular number, Young's modulus, yield strength, and ultimate strength.
In this study, a high degree of SDE was demonstrated in the VIS, which indicates that the conventional technique is unreliable. Additionally, accurate sample fabrication and credible quantitative analysis of local trabeculae among individuals can be achieved with the aid of computed tomography and the 3DP device, thus providing a more objective method for researching musculoskeletal degenerative diseases and possibly a better clinical understanding of these disorders.
在本研究中，我们提出了一种使用3D打印技术从人股骨头中准确提取小梁的新方法，并比较了这种新方法与传统方法之间的空间偏差误差。我们发现，表明不准确和不可靠的空间偏差误差在传统方法中显著更高。
局部骨的结构和力学性能评估在与肌肉骨骼退行性疾病相关的病理变化研究中很重要。然而，广泛使用的小梁柱视觉提取方法（VIS）与真实性存在很大偏差，称为空间偏差误差（SDE）。在此，我们提出一种使用3D打印（3DP）定位装置准确定位和钻取小梁的新方法，并评估VIS的SDE。
从骨质疏松患者中获取20个股骨头，通过VIS（n = 10）或3DP（n = 10）方法从主要压缩小梁中提取小梁柱。比较两组之间的形态、结构和力学性能以及记录的空间偏差误差。
与3DP组相比，VIS组中心轴偏转的平均角度显著更大；VIS组在骨密度、骨体积/组织体积比、小梁厚度、小梁数量、杨氏模量、屈服强度和极限强度方面的SDE分别高出26.1%、8.8%、4.1%、9.8%、7.2%、8.1%和10.1%。
在本研究中，VIS显示出高度的SDE，这表明传统技术不可靠。此外，借助计算机断层扫描和3DP装置可以实现个体间局部小梁的精确样本制作和可靠的定量分析，从而为研究肌肉骨骼退行性疾病提供更客观的方法，并可能对这些疾病有更好的临床理解。
