从洛氏链霉菌中鉴定巴佛洛霉素生物合成基因簇。
Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.
机构信息
Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao, Shandong 266101, PR China.
出版信息
Chembiochem. 2013 Feb 11;14(3):301-6. doi: 10.1002/cbic.201200743. Epub 2013 Jan 29.
Abstract
New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering.
摘要
新希望
古老骨骼的新希望：普乐可霉素巴弗洛霉素作为一种抗骨质疏松药物已经探索了几十年。然而，其结构的复杂性限制了类似物的合成。从环境分离株洛氏链霉菌中克隆巴弗洛霉素生物合成基因簇为通过生物工程生产新类似物打开了大门。
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