由链霉菌 sp. CS 产生的巴弗洛霉素族大环内酯类
Macrolides of the bafilomycin family produced by Streptomyces sp. CS.
机构信息
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Fujian, PR China.
出版信息
J Antibiot (Tokyo). 2010 Oct;63(10):595-9. doi: 10.1038/ja.2010.95. Epub 2010 Sep 8.
Five new 16-membered macrolides (1-5), belonging to the bafilomycin subfamily, were isolated from the fermentation broth of Streptomyces sp. CS, a commensal microbe of Maytenus hookeri. Their structures including relative configurations were elucidated based on NMR data and analysis of single crystal X-ray diffraction data. The cytotoxicities of compounds 1-5 on the MDA-MB-435 cell line were analyzed by the MTT method and the IC(50) values were found to be 4.2, 4.5, 5.5, 3.8 and 11.4 μM, respectively.
从卫矛科美登木共生微生物链霉菌 CS 的发酵液中分离得到五个新的 16 元大环内酯化合物（1-5），属于巴佛洛霉素亚科。根据 NMR 数据和单晶 X 射线衍射数据分析，确定了它们的结构包括相对构型。采用 MTT 法分析了化合物 1-5 对 MDA-MB-435 细胞系的细胞毒性，IC50 值分别为 4.2、4.5、5.5、3.8 和 11.4 μM。
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