Department of Urology, University of Texas Health San Antonio, San Antonio, TX, USA.
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, USA.
Urologia. 2024 Feb;91(1):90-106. doi: 10.1177/03915603231202304. Epub 2023 Sep 30.
The major barriers to phytonutrients in prostate cancer therapy are non-specific mechanisms and bioavailability issues. Studies have pointed to a synergistic combination of curcumin (CURC) and ursolic acid (UA). We investigate this combination using a systematic review process to assess the most likely mechanistic pathway and human testing in prostate cancer. We used the PRISMA statement to screen titles, abstracts, and the full texts of relevant articles and performed a descriptive analysis of the literature reviewed for study inclusion and consensus of the manuscript. The most common molecular and cellular pathway from articles reporting on the pathways and effects of CURC ( = 173) in prostate cancer was NF-κB ( = 25, 14.5%). The most common molecular and cellular pathway from articles reporting on the pathways and effects of UA ( = 24) in prostate cancer was caspase 3/caspase 9 ( = 10, 41.6%). The three most common molecular and cellular pathway from articles reporting on the pathways and effects of both CURC and UA ( = 193) in prostate cancer was NF-κB ( = 28, 14.2%), Akt ( = 22, 11.2%), and androgen ( = 19, 9.6%). Therefore, we have identified the potential synergistic target pathways of curcumin and ursolic acid to involve NF-κB, Akt, androgen receptors, and apoptosis pathways. Our review highlights the limited human studies and specific effects in prostate cancer.
植物化学素在前列腺癌治疗中的主要障碍是非特异性机制和生物利用度问题。研究表明，姜黄素（CUR）和熊果酸（UA）的协同组合。我们通过系统评价过程研究了这种组合，以评估其在前列腺癌中最可能的机制途径和人体试验。我们使用 PRISMA 声明筛选标题、摘要和相关文章的全文，并对文献进行描述性分析，以评估研究纳入和手稿共识。在报道 CUR 在前列腺癌中的途径和作用的文章（ = 173）中，最常见的分子和细胞途径是 NF-κB（ = 25，14.5%）。在报道 UA 在前列腺癌中的途径和作用的文章（ = 24）中，最常见的分子和细胞途径是 caspase 3/caspase 9（ = 10，41.6%）。在报道 CUR 和 UA 在前列腺癌中的途径和作用的文章（ = 193）中，最常见的三个分子和细胞途径是 NF-κB（ = 28，14.2%）、Akt（ = 22，11.2%）和雄激素（ = 19，9.6%）。因此，我们已经确定了姜黄素和熊果酸的潜在协同作用靶点途径，涉及 NF-κB、Akt、雄激素受体和凋亡途径。我们的综述强调了在前列腺癌中人类研究和特定作用的局限性。
