结节病及其他肉芽肿性疾病中的血清血管紧张素转换酶（SACE）

Serum angiotensin-converting enzyme (SACE) in sarcoidosis and other granulomatous disorders.

作者信息

Studdy P, Bird R, James D G

出版信息

Lancet. 1978;2(8104-5):1331-4. doi: 10.1016/s0140-6736(78)91972-4.

DOI:10.1016/s0140-6736(78)91972-4

Abstract

Serum angiotensin-converting enzyme (SACE) activity was significantly higher in 90 patients with sarcoidosis (55 +/- [S.D.] 23 nmol min-1 ml-1) than in 80 healthy controls (34 +/- 9 nmol min-1 ml-1). Steroid therapy modified SACE activity; 60 sarcoidosis patients who were not being treated with steroids had significantly higher enzyme activities (58 +/- 24 nmol min-1 ml-1) than 30 steroid-treated sarcoidosis patients (40 +/- 19 nmol min-1 ml-1). In 50% of the non-steroid treated sarcoidosis patients SACE activity was more than 2 S.D. above the mean value for the controls. SACE activity was measured in 22 tuberculous patients (38 +/- 14 nmol min-1 ml-1), 20 leprosy patients (34 +/- 9 nmol min-1 ml-1), 31 with primary biliary cirrhosis (44 +/- 20 nmol min-1 ml-1), 26 with inflammatory bowel disease (31 +/- 9 nmol min-1 ml-1), 8 with hepatic granulomatous disease, 5 with Hodgkin's disease, and 2 with schistosomiasis. The combined false-positive rate for these non-sarcoidosis patients was 10%. Serial SACE assays provide useful information on the course of sarcoidosis and response to steroid treatment.

摘要

90例结节病患者的血清血管紧张素转换酶（SACE）活性（55±[标准差]23nmol·min⁻¹·ml⁻¹）显著高于80例健康对照者（34±9nmol·min⁻¹·ml⁻¹）。类固醇疗法改变了SACE活性；60例未接受类固醇治疗的结节病患者的酶活性（58±24nmol·min⁻¹·ml⁻¹）显著高于30例接受类固醇治疗的结节病患者（40±19nmol·min⁻¹·ml⁻¹）。在50%未接受类固醇治疗的结节病患者中，SACE活性比对照者的平均值高出2个标准差以上。对22例肺结核患者（38±14nmol·min⁻¹·ml⁻¹）、20例麻风病患者（34±9nmol·min⁻¹·ml⁻¹）、31例原发性胆汁性肝硬化患者（44±20nmol·min⁻¹·ml⁻¹）、26例炎症性肠病患者（31±9nmol·min⁻¹·ml⁻¹）、8例肝肉芽肿病患者、５例霍奇金病患者和2例血吸虫病患者进行了SACE活性检测。这些非结节病患者的联合假阳性率为10%。连续进行SACE检测可为结节病的病程及对类固醇治疗的反应提供有用信息。