Neuro-Ophthalmology Unit, Rabin Medical Center, Petach Tikva, Israel.
Neuroepidemiology. 2013;40(3):220-4. doi: 10.1159/000342155. Epub 2013 Jan 24.
To compare the incidence of cardiac and cerebrovascular events following non-arteritic anterior ischemic optic neuropathy (NAION) compared to published control data using the Framingham, United Kingdom Prospective Diabetes Study (UKPDS) and the National Vascular Disease Prevention Alliance (NVDPA) data.
A retrospective study of all consecutive cases of NAION between 1990 and 2005. Patients were stratified into those with or without prior ischemic events and into diabetics and non-diabetics. Outcome measures included cardiovascular morbidity, cerebrovascular events and the Framingham, UKPDS and NVDPA scores for each patient.
According to the NVDPA, the average absolute 5-year risk for cardiovascular disease (CVD) was 8.98, compared to 9 CVD events in our study. In the diabetic patients, 5 (17%) had a cardiac event and 2 (8%) had a cerebral vascular accident (CVA). Based on the UKPDS risk calculator, the average 10-year risk for cardiac events is 21.6%, CVA -6.8%. In the non-diabetics, there were 3 cases (7.5%) of myocardial infarction, compared to the average 10-year Framingham risk for myocardial infarction or coronary death of 11% (±8 SD).
Following NAION, the incidence of cardiovascular or cerebrovascular events in patients taking aspirin is not in major excess from that expected in risk-factor age-matched controls.
与Framingham、英国前瞻性糖尿病研究（UKPDS）和国家血管疾病预防联盟（NVDPA）的数据相比，比较非动脉炎性前部缺血性视神经病变（NAION）后心脏和脑血管事件的发生率。
这是一项对 1990 年至 2005 年间连续发生的所有 NAION 病例的回顾性研究。患者分为有或无缺血事件以及糖尿病和非糖尿病患者。主要观察指标包括心血管发病率、脑血管事件以及每位患者的Framingham、UKPDS 和 NVDPA 评分。
根据 NVDPA，心血管疾病（CVD）的平均 5 年绝对风险为 8.98%，而我们的研究中则有 9 例 CVD 事件。在糖尿病患者中，有 5 例（17%）发生了心脏事件，2 例（8%）发生了脑血管意外（CVA）。根据 UKPDS 风险计算器，心脏事件的平均 10 年风险为 21.6%，CVA 为 6.8%。在非糖尿病患者中，有 3 例（7.5%）心肌梗死，而Framingham 风险模型预测的非糖尿病患者 10 年心肌梗死或冠心病死亡的平均风险为 11%（±8SD）。
NAION 后，服用阿司匹林的患者发生心血管或脑血管事件的发生率与年龄匹配的风险因素对照组预期的发生率没有明显增加。
