Li Xiaochun, Cao Xiaolu, Ma Fenglou, Jia Peipei, Wang Fuyin, Cao Xiaoguang
Department of Ophthalmology, Peking University International Hospital, Beijing, China.
Center of Optometry, Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, 11# Xizhimen South Street, Xicheng District, Beijing 100044, China.
Transl Neurosci. 2023 Mar 18;14(1):20220281. doi: 10.1515/tnsci-2022-0281. eCollection 2023 Jan 1.
The aim of this study was to explore the correlation between non-arteritic anterior ischemic optic neuropathy (NAION) and cerebral infarction (CI). Moreover, the ocular and systemic parameters are also compared between NAION patients with or without CI.
Retrospective analysis is performed for NAION patients and the controls. The controls were collected at the eye outpatient with cranial computed tomography (CT), and data of blood triglyceride, cholesterol, low-density lipoprotein, high-density lipoprotein, and apolipoprotein B were drawn. The diagnosed NAION patients with cranial CT are included, and data of clinical history and routine clinical examination were drawn from the medical record. Visual acuity, intraocular pressure (IOP), visual field, and visual evoked potential were also drawn.
Eighty-two unilateral and 6 bilateral patients, totally 94 eyes for 88 NAION patients and 69 controls are included. NAION and control patients have matched age, gender, and weight. There is no difference in triglyceride, cholesterol, low-density lipoprotein, high-density lipoprotein, and apolipoprotein B between these two groups. NAION patients (43.18%, 38/88) have a higher ratio of CI than the controls (14.49%, 10/69) ( = 0.000). For NAION, the odds ratio (OR) of CI is 2.691 ( = 0.011). Body mass index, height, and IOP show no significant difference between NAION patients with or without CI. NAION patients with CI have a significant higher ratio of hypertension than those without CI, and the OR of HBP is 2.623 ( = 0.008).
The correlation between NAION and CI is possible as NAION patients have a significant higher ratio with CI. In NAION patients, hypertension is a risk factor for those with CI.
本研究旨在探讨非动脉炎性前部缺血性视神经病变（NAION）与脑梗死（CI）之间的相关性。此外，还比较了合并或未合并CI的NAION患者的眼部和全身参数。
对NAION患者和对照组进行回顾性分析。对照组在眼科门诊进行头颅计算机断层扫描（CT）检查，并采集血甘油三酯、胆固醇、低密度脂蛋白、高密度脂蛋白和载脂蛋白B的数据。纳入经头颅CT确诊的NAION患者，并从病历中提取临床病史和常规临床检查数据。还记录了视力、眼压（IOP）、视野和视觉诱发电位。
纳入88例NAION患者的94只眼（其中82例单侧，6例双侧）和69例对照组。NAION患者和对照组在年龄、性别和体重方面相匹配。两组之间的甘油三酯、胆固醇、低密度脂蛋白、高密度脂蛋白和载脂蛋白B无差异。NAION患者的CI发生率（43.18%，38/88）高于对照组（14.49%，10/69）（P = 0.000）。对于NAION，CI的比值比（OR）为2.691（P = 0.011）。体重指数、身高和眼压在合并或未合并CI的NAION患者之间无显著差异。合并CI的NAION患者高血压发生率显著高于未合并CI的患者，高血压的OR为2.623（P = 0.008）。
NAION与CI之间可能存在相关性，因为NAION患者合并CI的比例显著更高。在NAION患者中，高血压是合并CI患者的一个危险因素。
