Service of Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
Dement Geriatr Cogn Disord. 2013;35(1-2):87-97. doi: 10.1159/000346129. Epub 2013 Jan 29.
Both personality changes and behavioural and psychological symptoms (BPS) may be associated with mild cognitive impairment (MCI) in later life and help identify incipient dementia. We wished to investigate the links between personality and BPS in MCI.
We studied premorbid personality traits as estimated 5 years back and their changes in 83 control subjects and 52 MCI patients using the revised NEO Personality Inventory for the Five-Factor Model completed by a proxy. Information on BPS was obtained using the Neuropsychiatric Inventory (NPI). Analyses were controlled for current depression and anxiety.
Premorbid neuroticism and openness to experience were associated with the total NPI score. The changes in neuroticism, extraversion, openness to experiences, and conscientiousness were associated with apathy and affective symptoms.
Personality changes and BPS occur in MCI. The occurrence of affective BPS and apathy is associated with both premorbid personality traits and their changes.
人格改变和行为及心理症状（BPS）都可能与老年轻度认知障碍（MCI）相关，并有助于识别早期痴呆。我们希望研究 MCI 中人格与 BPS 之间的联系。
我们使用修订后的五因素模型 NEO 人格量表评估了 83 名对照受试者和 52 名 MCI 患者的 5 年前的人格特质及其变化情况，这些评估结果由代理人完成。使用神经精神病学问卷（NPI）获取 BPS 信息。分析时控制了当前的抑郁和焦虑情况。
MCI 患者的术前神经质和开放性与 NPI 总分相关。神经质、外向性、开放性和责任心的变化与冷漠和情感症状相关。
MCI 患者会出现人格改变和 BPS。情感 BPS 和冷漠的发生与术前人格特质及其变化均相关。
