Institute de recherché société et sante, Université Catholique de Louvain, Brussels, Belgium.
J Nutr Health Aging. 2013 Feb;17(2):107-11. doi: 10.1007/s12603-012-0094-0.
Hypovitaminosis D and chronic kidney disease (CKD) are highly prevalent in older adults. The factors correlating with 25-OH-vitamin D and PTH levels were analyzed in older adults with and without CKD.
We performed a cross-sectional analysis embedded within the BELFRAIL study.
A population-based prospective cohort study of the very elderly in Belgium.
325 participants, all aged 80 or older.
Time of year and LAPAQ score were used as proxies for sunshine exposure. Vitamin D3 supplementation, gender, institutionalisation, age, level of education, and serum calcium and phosphorus level were examined as possible confounders in the analyses.
There was no correlation between the presence of CKD and low 25-OH-vitamin D levels, but there was a significant (p<0.01) correlation between CKD and high PTH levels. Among the participants with a normal eGFR, the LAPACQ score, vitamin D supplementation, season, log PTH value and eGFR were correlated with log 25-OH-vitamin D levels. Among the participants with CKD, only vitamin D supplementation, log PTH levels and serum calcium levels were correlated with log 25-OH-vitamin D levels. Gender, log 25-OH-vitamin D values, serum calcium and phosphorus levels and eGFR were correlated with log PTH values in the patients with normal eGFR. Log 25-OH-vitamin D values, serum phosphorus levels, vitamin D supplementation (p=0.07), season (p=0.10) and eGFR were correlated with log PTH values in the patients with CKD.
Exposure to sunshine and an active lifestyle were correlated with higher 25-OH-vitamin D levels in older adults without CKD. The PTH level in patients with CKD may be influenced by the season.
维生素 D 缺乏症和慢性肾脏病（CKD）在老年人中极为普遍。本研究旨在分析伴有和不伴有 CKD 的老年人中与 25-羟维生素 D 和 PTH 水平相关的因素。
本研究为 BELFRAIL 研究中的一项横断面分析。
比利时一项针对非常高龄老年人的基于人群的前瞻性队列研究。
325 名参与者，年龄均在 80 岁或以上。
一年中的时间和 LAPAQ 评分被用作阳光暴露的替代指标。维生素 D3 补充、性别、机构化、年龄、教育程度以及血清钙和磷水平被视为分析中的可能混杂因素。
CKD 的存在与低 25-羟维生素 D 水平之间无相关性，但与高 PTH 水平之间存在显著相关性（p<0.01）。在 eGFR 正常的参与者中，LAPACQ 评分、维生素 D 补充、季节、PTH 对数和 eGFR 与 log25-羟维生素 D 水平相关。在 CKD 患者中，只有维生素 D 补充、PTH 对数和血清钙水平与 log25-羟维生素 D 水平相关。在 eGFR 正常的患者中，性别、log25-羟维生素 D 值、血清钙和磷水平以及 eGFR 与 PTH 对数相关。log25-羟维生素 D 值、血清磷水平、维生素 D 补充（p=0.07）、季节（p=0.10）和 eGFR 与 CKD 患者的 PTH 对数相关。
在不伴有 CKD 的老年人中，阳光暴露和积极的生活方式与较高的 25-羟维生素 D 水平相关。CKD 患者的 PTH 水平可能受季节影响。
