Servicio de Pediatría. Unidad de Nefrología Pediátrica. Hospital Universitario de Getafe, Madrid Spain.
Nefrologia. 2013 Jan 18;33(1):61-9. doi: 10.3265/Nefrologia.pre2012.Jul.11484.
Studies examining health-related quality of life (HRQOL) in adults with chronic kidney disease (CKD) have demonstrated that certain clinical situations such as number of hospitalisations and anaemia can affect patient quality of life. Very few such studies have been carried out in children.
To analyse the impact of laboratory variables and various clinical situations on HRQOL of paediatric CKD patients.
We carried out a cross-sectional study using the TECAVNER questionnaire in 71 children with CKD and their parents (33 transplanted patients, 11 on peritoneal dialysis, 5 on haemodialysis, and 22 on conservative treatment). We analysed laboratory variables (blood urea nitrogen, creatinine, haematocrit, and albumin), clinical situation (short stature, arterial hypertension, and bone deformities), number of hospitalisations, and days spent in the hospital in the previous 6 months, as well as number of drugs administered and fluids/diet restrictions.
The factor that most heavily affected the quality of life of our patients was water restrictions. In addition, hypertension affected cognitive function in these children. A haematocrit value >35% improved physical activity and functionality. We observed no association between albumin and HRQOL.
These results confirm previous hypotheses and contribute to the validity of the TECAVNER questionnaire.
研究表明，某些临床情况（如住院次数和贫血）会影响慢性肾脏病（CKD）成人患者的健康相关生活质量（HRQOL）。但针对儿童患者的此类研究却非常少。
分析实验室变量和各种临床情况对儿科 CKD 患者 HRQOL 的影响。
我们采用 TECAVNER 问卷对 71 名 CKD 患儿及其家长（33 名移植患者、11 名腹膜透析患者、5 名血液透析患者和 22 名保守治疗患者）进行了横断面研究。我们分析了实验室变量（血尿素氮、肌酐、血细胞比容和白蛋白）、临床情况（身材矮小、高血压和骨畸形）、6 个月内的住院次数和住院天数，以及使用的药物数量和液体/饮食限制。
对我们患者的生活质量影响最大的因素是水限制。此外，高血压会影响这些儿童的认知功能。血细胞比容值＞35%会改善身体活动和功能。我们未观察到白蛋白与 HRQOL 之间存在关联。
这些结果证实了之前的假设，并提高了 TECAVNER 问卷的有效性。
