Department of Pediatrics, Kyungpook National University Children's Hospital, 807, Hoguk-ro, Buk-gu, Daegu, 41404, Republic of Korea.
Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
Pediatr Nephrol. 2017 Nov;32(11):2097-2105. doi: 10.1007/s00467-017-3721-5. Epub 2017 Jul 6.
The goal of this study was to evaluate the quality of life (QOL) of Asian children with pre-dialysis chronic kidney disease (CKD) and to reveal the factors influencing the QOL of children with CKD.
We performed a cross-sectional study of the PedsQL 4.0 Generic Core Scale Module in the KNOW-PedCKD (KoreaN cohort study for Outcome in patients with Pediatric Chronic Kidney Disease) cohort, and compared the child self-reported and parent proxy-reported QOL of the pediatric cohort. From 2011 through 2016, a total of 376 children with CKD were enrolled after informed consent was obtained from parents or caregivers in seven pediatric nephrology centers.
In parent proxy-reports, male patients had a better QOL than female patients in the Physical Functioning category. In child self-reports, male patients had better QOL than female patients in the Physical, Emotional, and School Functioning categories. According to CKD stage, there were significant differences in the QOL score in all categories of parent proxy-reports, and patients with higher CKD stage (lower glomerular filtration rate) had a worse QOL. Growth parameters showed a significantly positive correlation with the QOL score in all categories.
The QOL of children with predialysis CKD is affected by various factors, including sex, glomerular filtration rate (GFR), socio-economic status, existence of co-morbidities, anemia, growth retardation, and behavioral disorders. To improve their QOL, it is important to objectively understand the respective effects of these factors and attempt early intervention.
本研究旨在评估亚洲预透析慢性肾脏病（CKD）儿童的生活质量（QOL），并揭示影响CKD 儿童 QOL 的因素。
我们对 KNOW-PedCKD（韩国儿科慢性肾脏病患者结局研究）队列中的 PedsQL 4.0 通用核心量表模块进行了横断面研究，并比较了儿科队列中儿童自我报告和家长代理报告的 QOL。2011 年至 2016 年，在七个儿科肾病中心获得家长或看护人知情同意后，共纳入 376 例 CKD 患儿。
在家长代理报告中，男性患者在身体功能方面的 QOL 优于女性患者。在儿童自我报告中，男性患者在身体、情感和学业功能方面的 QOL 优于女性患者。根据 CKD 分期，家长代理报告的所有类别中 QOL 评分均有显著差异，且 CKD 分期较高（肾小球滤过率较低）的患者 QOL 较差。生长参数与所有类别中的 QOL 评分均呈显著正相关。
预透析 CKD 儿童的 QOL 受多种因素影响，包括性别、肾小球滤过率（GFR）、社会经济状况、共存疾病、贫血、生长迟缓、行为障碍等。为了提高他们的 QOL，重要的是要客观了解这些因素的各自影响，并尝试早期干预。
