Tehrani Hamid, McArthur Paul, Dalal Milind
Whiston Hospital, Liverpool; and †Royal Preston Hospital, Preston, United Kingdom.
Ann Plast Surg. 2013 Jun;70(6):717-9. doi: 10.1097/SAP.0b013e31824689a1.
The formation of cutaneous carcinoma has been shown to rely on neovascularization, with angiogenesis being implicated in the invasive process of skin malignancy and metastasis. To date, studies of angiogenesis have generally been limited to in vitro, animal (often murine), or postexcision histopathologic models.
To demonstrate the angiogenic progression of human tumors in vivo, this study has used the Spectrophotometric Intracutaneous Analyser (SIAscope; Biocompatibles, Surrey, United Kingdom) to produce parametric images of 250 nonmelanoma skin cancers and 13 actinic keratoses. This provides a history, in images, of the vascular basis of skin cancer formation.
While displaying that the in vitro findings of angiogenesis are indeed occurring in vivo in humans, this technique also suggests a practical means to allow accurate application and monitoring of antiangiogenic therapy. In addition, it raises the possibility of differentiating superficial from nonsuperficial nonmelanoma skin cancers in an office-based setting, thus allowing accurate usage of surgical or nonsurgical treatment methods.
已有研究表明皮肤癌的形成依赖于新血管形成，血管生成与皮肤恶性肿瘤的侵袭过程和转移有关。迄今为止，血管生成的研究通常局限于体外、动物（通常是小鼠）或切除后的组织病理学模型。
为了在体内证明人类肿瘤的血管生成进展，本研究使用分光光度皮内分析仪（SIAscope；Biocompatibles，英国萨里）生成了250例非黑色素瘤皮肤癌和13例光化性角化病的参数图像。这以图像的形式提供了皮肤癌形成的血管基础的历程。
该技术不仅表明血管生成的体外研究结果确实在人类体内发生，还提出了一种切实可行的方法，可用于抗血管生成治疗的准确应用和监测。此外，它还增加了在门诊环境中区分浅表性和非浅表性非黑色素瘤皮肤癌的可能性，从而能够准确使用手术或非手术治疗方法。
