De Sanctis Pierfilippo, Butler John S, Green Jason M, Snyder Adam C, Foxe John J
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:1542-5. doi: 10.1109/EMBC.2012.6346236.
The present study investigated the feasibility of acquiring high-density event-related brain potential (ERP) recordings during treadmill walking in human subjects. The work builds upon recent studies testing the applicability of real-world tasks while obtaining electroencephalographic (EEG) recordings. Participants performed a response inhibition GO/NOGO task - designed to evoke a P3 component for correct response inhibitions and an error-related negativity (ERN) for incorrect commission errors - while speed of walking was experimentally manipulated. Robust P3 and ERN components were obtained under all experimental conditions - while participants were sitting, walking at moderate speed (2.4 km/hour), or walking rapidly (5 km/hour). Signal-to-noise ratios were remarkably similar across conditions, pointing to the feasibility of high-fidelity ERP recordings under relatively vigorous activity regimens. There is considerable research and clinical motivation to obtain high quality neurophysiological measures under more naturalistic environmental settings such as these. Strong links between cognitive load and gait abnormalities are seen in a number of clinical populations and these MoBI technologies provide highly promising methods for gaining insights into the underlying pathophysiology.
本研究调查了在人类受试者跑步机行走过程中获取高密度事件相关脑电位（ERP）记录的可行性。这项工作建立在近期研究的基础上，这些研究在获取脑电图（EEG）记录的同时测试现实世界任务的适用性。参与者执行了一个反应抑制“走/不走”任务——该任务旨在为正确的反应抑制诱发一个P3成分，为错误的执行错误诱发一个错误相关负波（ERN）——同时对行走速度进行实验性操纵。在所有实验条件下——参与者坐着、以中等速度（2.4公里/小时）行走或快速行走（5公里/小时）时——均获得了稳健的P3和ERN成分。不同条件下的信噪比非常相似，这表明在相对剧烈的活动方案下进行高保真ERP记录是可行的。在这样更自然的环境设置下获得高质量神经生理学测量结果有相当多的研究和临床动机。在许多临床人群中都观察到认知负荷与步态异常之间有紧密联系，这些移动脑/体成像（MoBI）技术为深入了解潜在病理生理学提供了非常有前景的方法。
