The Sheryl & Daniel R. Tishman Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC), Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Program in Cognitive Neuroscience, The Graduate Center of the City University of New York, New York, NY 10016, USA.
The Sheryl & Daniel R. Tishman Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC), Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Program in Cognitive Neuroscience, The Graduate Center of the City University of New York, New York, NY 10016, USA; The Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; The Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Intellectual and Developmental Disabilities Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Trinity College Institute of Neuroscience, Dublin, Ireland.
Brain Res. 2019 Aug 1;1716:62-69. doi: 10.1016/j.brainres.2017.05.021. Epub 2017 May 19.
Advancements in acquisition technology and signal-processing techniques have spurred numerous recent investigations on the electro-cortical signals generated during whole-body motion. This approach, termed Mobile Brain/Body Imaging (MoBI), has the potential to elucidate the neural correlates of perceptual and cognitive processes during real-life activities, such as locomotion. However, as of yet, no one has assessed the long-term stability of event-related potentials (ERPs) recorded under these conditions. Therefore, the objective of the current study was to evaluate the test-retest reliability of cognitive ERPs recorded while walking. High-density EEG was acquired from 12 young adults on two occasions, separated by an average of 2.3years, as they performed a Go/No-Go response inhibition paradigm. During each testing session, participants performed the task while walking on a treadmill and seated. Using the intraclass correlation coefficient (ICC) as a measure of agreement, we focused on two well-established neurophysiological correlates of cognitive control, the N2 and P3 ERPs. Following ICA-based artifact rejection, the earlier N2 yielded good to excellent levels of reliability for both amplitude and latency, while measurements for the later P3 component were generally less robust but still indicative of adequate to good levels of stability. Interestingly, the N2 was more consistent between walking sessions, compared to sitting, for both hits and correct rejection trials. In contrast, the P3 waveform tended to have a higher degree of consistency during sitting conditions. Overall, these results suggest that the electro-cortical signals obtained during active walking are representative of stable indices of neurophysiological function.
采集技术和信号处理技术的进步推动了最近对全身运动期间产生的电皮质信号的大量研究。这种方法称为移动大脑/身体成像（MoBI），有可能阐明在现实生活活动（如运动）期间感知和认知过程的神经相关性。然而，到目前为止，还没有人评估过在这些条件下记录的事件相关电位（ERP）的长期稳定性。因此，本研究的目的是评估在行走时记录的认知 ERP 的测试-重测可靠性。在两次测试中，从 12 名年轻人那里获取高密度 EEG，两次测试之间的平均间隔为 2.3 年，他们在执行 Go/No-Go 反应抑制范式时进行了测试。在每次测试期间，参与者在跑步机上和座位上行走时执行任务。使用组内相关系数（ICC）作为一致性的衡量标准，我们重点关注认知控制的两个成熟的神经生理学相关性，即 N2 和 P3 ERP。在基于 ICA 的伪影剔除之后，早期的 N2 对于振幅和潜伏期都产生了良好到优秀的可靠性水平，而后期 P3 成分的测量通常不太可靠，但仍然表明具有足够到良好的稳定性水平。有趣的是，与坐姿相比，N2 在行走过程中对于击中与正确拒绝试验都具有更高的一致性。相比之下，P3 波形在坐姿条件下往往具有更高的一致性。总体而言，这些结果表明在主动行走期间获得的电皮质信号是神经生理功能稳定指标的代表。
