Rejmstad Peter, Åkesson Gustav, Hillman Jan, Wårdell Karin
Department of Biomedical Engineering, Linköping University, Sweden.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:1988-91. doi: 10.1109/EMBC.2012.6346346.
A two-channel standard laser Doppler perfusion monitor has been adapted for intracerebral measurements. Software developed in Labview makes it possible to present the microvascular perfusion, total light intensity (TLI), heart rate and trend curves in real-time during surgery. A custom-made optical probe was designed in order to enable easy fixation during brain surgery. The constructed brain probe was evaluated and compared to a standard probe. Both probes presented similar feasibility when used for the skin recordings. In addition, evaluation was done in one patient in relation to tumor resection. Stable perfusion and TLI signals were immediately recorded when the probe was positioned in cerebral tissue. Movement artifacts were clearly seen when the probe was moved to a new site. Recordings in cortex and tumor border showed higher perfusion and lower TLI compared to measurements in subcortical white matter. The calculated heart rate estimate agreed well with the noted value from the electrocardiographic patient monitoring system.
一种双通道标准激光多普勒灌注监测仪已被改装用于脑内测量。用Labview开发的软件能够在手术过程中实时呈现微血管灌注、总光强（TLI）、心率和趋势曲线。设计了一种定制的光学探头，以便在脑外科手术中易于固定。对构建的脑探头进行了评估，并与标准探头进行了比较。当用于皮肤记录时，两种探头都表现出相似的可行性。此外，对一名患者进行了与肿瘤切除相关的评估。当探头置于脑组织中时，立即记录到稳定的灌注和TLI信号。当探头移至新位置时，明显可见运动伪影。与皮质下白质测量相比，皮质和肿瘤边界的记录显示灌注更高、TLI更低。计算出的心率估计值与心电图患者监测系统记录的值吻合良好。
