Kitsios Konstantinos, Papadopoulou Maria, Kosta Konstantina, Kadoglou Nikolaos, Papagianni Maria, Tsiroukidou Kiriaki
G Gennimatas General Hospital, Department of Internal Medicine, Thessaloniki, Greece.
J Clin Res Pediatr Endocrinol. 2013;5(1):44-9. doi: 10.4274/Jcrpe.789. Epub 2013 Jul 1.
To compare high-sensitivity C-reactive protein (hsCRP) levels in obese and overweight children and adolescents to normal-weight individuals as well as to compare hsCRP levels in overweight children/adolescents with and without additional metabolic disorders such as metabolic syndrome (MS), non-alcoholic fatty liver disease (NAFLD), and prediabetes.
54 consecutive obese children and adolescents with a body mass index (BMI) ≥ 95th centile and 50 overweight children and adolescents with BMI values between 85th and 95th centiles were screened for MS, prediabetes and NAFLD. Serum hsCRP levels were measured in all the participants and in 40 age-matched normal-weight individuals (controls).
HsCRP levels were significantly increased in obese and overweight subjects as compared to the control group, (0.61 ± 1.08 vs. 0.05 ± 0.18 mg/dL,p<0.001 and 0.33 ± 0.25 vs. 0.05 ± 0.18 mg/dL, p<0.001, respectively). HsCRP levels were similar between obese and overweight subjects (p=0.109). Obese and overweight children with NAFLD had significantly higher levels of hsCRP compared to their counterparts without NAFLD (0.78 ± 1.4 vs. 0.34 ± 0.31 mg/dL, p=0.016). The levels of hsCRP were comparable in the obese and overweight children/adolescents with and without MS and with or without prediabetes(0.95 ± 1.66 vs. 0.35 ± 0.27 mg/dL, p = 0.096 and 0.43 ± 0.34 vs. 0.53 ± 1.0mg/dL, p=0.589, respectively).
HsCRP is significantly elevated in children and adolescents with excess weight as compared to normal-weight individuals. In addition,children and adolescents with excessive weight and NAFLD show increased levels of hsCRP compared to their counterparts with normal liver.
比较肥胖和超重儿童及青少年与正常体重个体的高敏C反应蛋白（hsCRP）水平，并比较伴有和不伴有代谢综合征（MS）、非酒精性脂肪性肝病（NAFLD）和糖尿病前期等其他代谢紊乱的超重儿童/青少年的hsCRP水平。
对54名连续入选的体重指数（BMI）≥第95百分位数的肥胖儿童和青少年以及50名BMI值在第85至第95百分位数之间的超重儿童和青少年进行MS、糖尿病前期和NAFLD筛查。测量所有参与者以及40名年龄匹配的正常体重个体（对照组）的血清hsCRP水平。
与对照组相比，肥胖和超重受试者的hsCRP水平显著升高（分别为0.61±1.08 vs. 0.05±0.18mg/dL，p<0.001和0.33±0.25 vs. 0.05±0.18mg/dL，p<0.001）。肥胖和超重受试者之间的hsCRP水平相似（p=0.109）。与无NAFLD的肥胖和超重儿童相比，患有NAFLD的肥胖和超重儿童的hsCRP水平显著更高（0.78±1.4 vs. 0.34±0.31mg/dL，p=0.016）。伴有和不伴有MS以及伴有和不伴有糖尿病前期的肥胖和超重儿童/青少年的hsCRP水平相当（分别为0.95±1.66 vs. 0.35±0.27mg/dL，p = 0.096和0.43±0.34 vs. 0.53±1.0mg/dL，p=0.589）。
与正常体重个体相比，超重的儿童和青少年的hsCRP显著升高。此外，与肝脏正常的儿童和青少年相比，体重过重且患有NAFLD的儿童和青少年的hsCRP水平升高。
