Halu Arda, Bianconi Ginestra
Department of Physics, Northeastern University, Boston, Massachusetts 02115, USA.
Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Dec;86(6 Pt 2):066101. doi: 10.1103/PhysRevE.86.066101. Epub 2012 Dec 3.
Recent studies on epistatic networks of model organisms have unveiled a certain type of modular property called monochromaticity in which the networks are clustered into functional modules that interact with each other through the same type of epistasis. Here, we propose and study three epistatic network models that are inspired by the duplication-divergence mechanism to gain insight into the evolutionary basis of monochromaticity and to test if it can be explained as the outcome of a neutral evolutionary hypothesis. We show that the epistatic networks formed by these stochastic evolutionary models have monochromaticity conflict distributions that are centered close to zero and are statistically significantly different from their randomized counterparts. In particular, the last model we propose yields a strictly monochromatic solution. Our results agree with the monochromaticity findings in real organisms and point toward the possible role of a neutral mechanism in the evolution of this phenomenon.
近期对模式生物上位性网络的研究揭示了一种称为单色性的模块化特性，即网络被聚类为功能模块，这些模块通过相同类型的上位性相互作用。在此，我们提出并研究了三种受复制-分化机制启发的上位性网络模型，以深入了解单色性的进化基础，并检验其是否可被解释为中性进化假说的结果。我们表明，由这些随机进化模型形成的上位性网络具有集中在零附近的单色性冲突分布，并且在统计上与它们的随机对应物有显著差异。特别是，我们提出的最后一个模型产生了一个严格单色的解决方案。我们的结果与真实生物中的单色性发现一致，并指出了中性机制在这一现象进化中的可能作用。
