Department of Chemical and Biomolecular Engineering, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Langmuir. 2013 Jun 18;29(24):7203-8. doi: 10.1021/la304580x. Epub 2013 Jan 31.
We report the preparation of degradable capsules via layer-by-layer assembly using polyelectrolyte (PE) polyrotaxanes (PRXs). The PRX capsules were prepared by the sequential deposition of PRXs onto silica particles followed by the dissolution of the silica cores. The colloidal stability of the PRX capsules that are formed depends on the salt/buffer solution used in the assembly process. Various salt/buffer combinations were examined to avoid aggregation of the core-shell particles during PRX assembly and core dissolution. Using appropriate assembly conditions, we prepared colloidally stable, robust capsules. PRX capsules consisting of eight layers of PE PRXs had a wall thickness of ~15 nm. The degradation of the PRX capsules was demonstrated through the disassembly of the PE PRXs using glutathione, which cleaves the disulfide bonds linking the end-capping groups of the PE PRXs. Given the supramolecular noncovalent structure of PRXs and their adjustable properties, it is expected that PRXs will be used as building blocks for assembling advanced capsules with unique and tailored properties.
我们报告了使用聚电解质（PE）聚轮烷（PRX）通过层层组装制备可降解胶囊的方法。PRX 胶囊是通过将 PRX 顺序沉积在二氧化硅颗粒上，然后溶解二氧化硅核来制备的。形成的 PRX 胶囊的胶体稳定性取决于组装过程中使用的盐/缓冲溶液。研究了各种盐/缓冲组合，以避免在 PRX 组装和核溶解过程中核壳颗粒的聚集。使用适当的组装条件，我们制备了胶体稳定、坚固的胶囊。由八层 PE PRX 组成的 PRX 胶囊的壁厚约为 15nm。通过使用谷胱甘肽（glutathione）分解连接 PE PRX 端封基团的二硫键，证明了 PRX 胶囊的降解。鉴于 PRXs 的超分子非共价结构及其可调节的性质，预计 PRXs 将被用作组装具有独特和定制性质的先进胶囊的构建块。
