二氟卡宾与有机锌试剂的反应。
Reactions of difluorocarbene with organozinc reagents.
机构信息
N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.
出版信息
Org Lett. 2013 Feb 15;15(4):917-9. doi: 10.1021/ol400122k. Epub 2013 Jan 31.
PMID:23368906
Abstract
Reactions of difluorocarbene with benzyl and alkylzinc halides leading to fluorinated organozinc species have been described. The generated α-difluorinated organozinc reagents are reasonably stable in solution and can be quenched with external electrophiles (iodine, bromine, proton), affording compounds containing the CF(2) fragment.
摘要
二氟卡宾与苄基和烷基卤化锌反应生成氟化有机锌物种的反应已有描述。生成的α-二氟代有机锌试剂在溶液中具有相当的稳定性，并且可以用外部亲电试剂（碘、溴、质子）猝灭，得到含有 CF(2)片段的化合物。
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