α,α-二氟取代的有机锌试剂与1-溴代炔烃的偶联反应。
Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes.
作者信息
Zemtsov Artem A, Volodin Alexander D, Levin Vitalij V, Struchkova Marina I, Dilman Alexander D
机构信息
N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.
N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation ; Higher Chemical College, Russian Academy of Sciences, 125047 Moscow, Miusskaya sq. 9, Russian Federation.
出版信息
Beilstein J Org Chem. 2015 Nov 10;11:2145-9. doi: 10.3762/bjoc.11.231. eCollection 2015.
α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free conditions.
由常规有机锌化合物和二氟卡宾生成的α,α-二氟取代有机锌试剂与1-溴代炔烃发生偶联反应，生成偕二氟代炔烃。该交叉偶联反应在无配体条件下，于二甲基甲酰胺中，在催化量的碘化亚铜存在下进行。
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