Programa de Pós-Graduação em Biologia Celular e Molecular, Universidade Federal do Rio Grande do Sul, Brazil.
FEBS J. 2013 Apr;280(7):1604-16. doi: 10.1111/febs.12159. Epub 2013 Feb 28.
Metallochaperones are key proteins for the safe transport of metallic ions inside the cell. HIPPs (heavy metal-associated isoprenylated plant proteins) are metallochaperones that contain a metal binding domain (HMA) and a C-terminal isoprenylation motif. In this study, we provide evidence that proteins of this family are found only in vascular plants and may be separated into five distinct clusters. HIPPs may be involved in (a) heavy metal homeostasis and detoxification mechanisms, especially those involved in cadmium tolerance, (b) transcriptional responses to cold and drought, and (c) plant-pathogen interactions. In particular, our results show that the rice (Oryza sativa) HIPP OsHIPP41 gene is highly expressed in response to cold and drought stresses, and its product is localized in the cytosol and the nucleus. The results suggest that HIPPs play an important role in the development of vascular plants and in plant responses to environmental changes.
金属伴侣蛋白是细胞内安全运输金属离子的关键蛋白。HIPPs（重金属结合的异戊烯基化植物蛋白）是金属伴侣蛋白，包含一个金属结合域（HMA）和一个 C 端异戊烯化基序。在这项研究中，我们提供的证据表明，该家族的蛋白质仅存在于维管植物中，并且可能分为五个不同的簇。HIPPs 可能参与（a）重金属的动态平衡和解毒机制，特别是与镉耐受相关的机制，（b）对寒冷和干旱的转录反应，以及（c）植物-病原体相互作用。特别是，我们的结果表明，水稻（Oryza sativa）HIPP OsHIPP41 基因在响应寒冷和干旱胁迫时高度表达，其产物定位于细胞质和细胞核中。这些结果表明，HIPPs 在维管植物的发育和植物对环境变化的反应中发挥着重要作用。
