蛋白质核磁共振的悄然复兴。
The quiet renaissance of protein nuclear magnetic resonance.
机构信息
Department of Biochemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232-8725, United States.
出版信息
Biochemistry. 2013 Feb 26;52(8):1303-20. doi: 10.1021/bi4000436. Epub 2013 Feb 12.
Abstract
From roughly 1985 through the start of the new millennium, the cutting edge of solution protein nuclear magnetic resonance (NMR) spectroscopy was to a significant extent driven by the aspiration to determine structures. Here we survey recent advances in protein NMR that herald a renaissance in which a number of its most important applications reflect the broad problem-solving capability displayed by this method during its classical era during the 1970s and early 1980s.
摘要
从大约 1985 年到新千年开始，溶液蛋白核磁共振（NMR）光谱学的最前沿在很大程度上受到确定结构的愿望所驱动。在这里，我们调查了蛋白质 NMR 的最新进展，这些进展预示着一种复兴，其中该方法的一些最重要的应用反映了该方法在 20 世纪 70 年代和 80 年代早期的经典时代所展示的广泛解决问题的能力。
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