糖尿病与慢性心力衰竭：从糖尿病性心肌病到治疗方法

Diabetes and chronic heart failure: from diabetic cardiomyopathy to therapeutic approach.

作者信息

Dei Cas A, Spigoni V, Ridolfi V, Metra M

机构信息

Unit of Diabetes and Prevention of Associated Diseases, Department of Clinical and Experimental Medicine, University of Parma, Italy.

出版信息

Endocr Metab Immune Disord Drug Targets. 2013 Mar;13(1):38-50. doi: 10.2174/1871530311313010006.

DOI:10.2174/1871530311313010006

PMID:23369136

Abstract

Diabetes and chronic heart failure are interrelated conditions with major medical and economic impact that have to be treated as a distinct entity. Several pathological mechanisms have been investigated and proposed to explain the structural and functional changes associated with diabetic cardiomyopathy. These mechanisms are likely to act synergically and may potentiate one the other. This review outlines recent advances in the pathophysiological mechanisms implicated in the development and progression of diabetic cardiomyopathy and in current therapeutic strategies.

摘要

糖尿病和慢性心力衰竭是相互关联的病症，具有重大的医学和经济影响，必须作为一个独特的实体来治疗。已经研究并提出了几种病理机制来解释与糖尿病性心肌病相关的结构和功能变化。这些机制可能协同作用，并且可能相互增强。本综述概述了与糖尿病性心肌病的发生和发展相关的病理生理机制以及当前治疗策略的最新进展。