糖尿病心肌病：定义、诊断和治疗意义。

Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications.

机构信息

IRCCS SDN, Via Gianturco 113, Naples 80142, Italy.

Department of Advanced Biomedical Sciences, Section of Cardiology, Federico II University of Naples, Via Sergio Pansini, 5, Naples 80131, Italy; Center for Congenital Heart Disease, University Hospital Inselspital, University of Bern, Freiburrgstrasse 18, Bern 3010, Switzerland.

出版信息

Heart Fail Clin. 2019 Jul;15(3):341-347. doi: 10.1016/j.hfc.2019.02.003. Epub 2019 Apr 5.

DOI:10.1016/j.hfc.2019.02.003

PMID:31079692

Abstract

A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.

摘要

糖尿病和心力衰竭之间存在严格的双向关系。糖尿病心肌病是糖尿病患者的一种特定心脏表现，其特征为早期左心室肥厚和舒张功能障碍，晚期出现收缩功能降低的心力衰竭。这种疾病的发病机制是多因素的，主要促进因素为胰岛素抵抗和高血糖的存在。糖尿病心肌病对受影响的患者产生负面影响，目前尚无针对该疾病的特效治疗方法。需要进一步努力以更好地定义该特殊情况下的诊断和治疗方法。