Department of Molecular Medicine, Hallym University College of Medicine, Chuncheon, South Korea.
Food Chem Toxicol. 2013 May;55:586-91. doi: 10.1016/j.fct.2013.01.022. Epub 2013 Jan 29.
Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10months; after this period. The OLETF rats were divided into the following four groups according to diet for 2months: NAFLD (chew), KRG (chew+KRG [200mg/kg/day]), urushiol (chew+urushiol [0.5mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew+UDCA [15mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0±70.4 and 275.2±63.8] vs. 527.7±153.3mg/dL) were lower compared with that of NAFLD group (p<0.05). The levels of HDL-cholesterol (liver tissue: [4.8±0.2 and 4.8±0.5] vs. 4.2±0.2mg/g) and NK cell activity ([3485±910 and 3559±910] vs. 2486±619 counts) were significantly higher than those of the NAFLD group (p<0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.
评价了高丽红参（KRG； Panax ginseng）和漆酚（Rhus vernicifera Stokes）对非酒精性脂肪性肝病（NAFLD）的抗氧化和免疫作用。45 只大鼠（5 只长野津岛大冢和 40 只大冢长野津岛肥胖[OLETF]大鼠）接受咀嚼饮食 10 个月；在此期间。OLETF 大鼠根据饮食分为以下四组 2 个月：NAFLD（咀嚼）、KRG（咀嚼+KRG[200mg/kg/天]）、漆酚（咀嚼+漆酚[0.5mg/kg/天]）和熊去氧胆酸（UDCA）（咀嚼+UDCA[15mg/kg/天]）组。比较了肝功能、血脂谱和肝、血清抗氧化活性、自然杀伤（NK）细胞活性和病理学。在 KRG 和漆酚组中，血清甘油三酯水平[（302.0±70.4 和 275.2±63.8）与 527.7±153.3mg/dL]低于 NAFLD 组（p<0.05）。HDL-胆固醇水平（肝组织：[4.8±0.2 和 4.8±0.5]与 4.2±0.2mg/g）和 NK 细胞活性[（3485±910 和 3559±910）与 2486±619 计数）明显高于 NAFLD 组（p<0.001）。仅在 NAFLD 组的两只大鼠中观察到伴有中性粒细胞浸润的炎症。这些结果表明，口服 KRG 或漆酚 2 个月可改善血脂谱并刺激 NK 细胞活性，同时抑制 OLEFT 大鼠的脂肪性肝炎。
