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[重症肌无力危象状态的发病机制]

[Pathomechanisms of myasthenic crisis states].

作者信息

Szobor A

出版信息

Psychiatr Neurol Med Psychol Beih. 1977;22-23:7-10.

PMID:233715
Abstract

From the point of view of the kind of fate of those people ill with myasthenia the crisis itself can be regarded as the most dangerous and usually the most problematic phenomenon. To the crisis belong all those conditions characteristic of serious respiratory failure and those occurring either as a direct result of myasthenia or due to other causes associated with other illnesses. Clinically, there are three main kinds of crisis: myasthenic, cholinergic, and oscillatory/,brittle". There is the possibility of 3 directions of study on the crisis: The careful analysis, coordination, and observation of the clinical picture, with precise notation of the course of the illness. Analysis of the neuro-muscular types of blockade which occur in myasthenia. Interpretation of changes such as resistance and intolerance observed during the process and which conform to the pathomechanism. The author deals with problems mentioned with regard to his casuistry of 300 people ill with myasthenia.

摘要

从重症肌无力患者的那种命运角度来看,危象本身可被视为最危险且通常是最具问题的现象。危象包括严重呼吸衰竭的所有特征性状况,以及那些要么直接由重症肌无力导致,要么因与其他疾病相关的其他原因而出现的状况。临床上,主要有三种危象:肌无力危象、胆碱能危象和波动/脆性危象。对危象有三种研究方向:仔细分析、协调和观察临床表现,并精确记录病程。分析重症肌无力中出现的神经肌肉阻滞类型。解释在病程中观察到的符合发病机制的诸如耐药性和不耐受性等变化。作者结合其对300例重症肌无力患者的病例分析来探讨上述问题。

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