King M J, Bowden M I, Cooper G M
Department of Anaesthetics, Birmingham Maternity Hospital, Queen Elizabeth Medical Centre.
Anaesthesia. 1990 Apr;45(4):285-8. doi: 10.1111/j.1365-2044.1990.tb14733.x.
Either 100 micrograms fentanyl or 2 ml saline was added to 0.5% bupivacaine administered epidurally for elective Caesarean section in 30 patients, in a double-blind randomised study. Bupivacaine 0.5% was administered until a complete sensory block was established extending to the 4th thoracic dermatome. One of the patients who received epidural fentanyl required intravenous alfentanil and Entonox and another, Entonox only briefly during surgery, compared with seven in the control group who required intravenous alfentanil and Entonox and one who required Entonox only. Postoperative analgesia was of longer duration in those who received epidural fentanyl (p less than 0.01). There were no deleterious effects on neonatal or maternal outcome.
在一项双盲随机研究中,30例行择期剖宫产的患者,硬膜外给予0.5%布比卡因时,要么添加100微克芬太尼,要么添加2毫升生理盐水。给予0.5%布比卡因直至建立起延伸至第4胸段皮节的完全感觉阻滞。接受硬膜外芬太尼的患者中有1例在手术期间需要静脉注射阿芬太尼和恩托诺克斯,另1例仅在手术期间短暂需要恩托诺克斯,而对照组中有7例需要静脉注射阿芬太尼和恩托诺克斯,1例仅需要恩托诺克斯。接受硬膜外芬太尼的患者术后镇痛持续时间更长(p<0.01)。对新生儿或产妇结局无不良影响。