G 蛋白偶联受体激活中的构象集合。
Conformational ensembles in GPCR activation.
机构信息
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Cell. 2013 Jan 31;152(3):385-6. doi: 10.1016/j.cell.2013.01.025.
PMID:23374334
Abstract
Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.
摘要
近年来，G 蛋白偶联受体结构生物学的进展仅为这些关键信号分子的活性构象提供了有限的了解。Nygaard 等人的论文通过将 NMR 实验与超长时间尺度分子动力学模拟相结合，揭示了 GPCR 在激活途径中的动态性质。
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