Biagi G, Livi O, Ramacciotti G L, Scartoni V, Bazzichi L, Mazzoni M R, Lucacchini A
Istituto di Chimica Farmaceutica e Tossicologica, Università di Pisa.
Farmaco. 1990 Jan;45(1):49-57. doi: 10.1002/chin.199037191.
This paper reports the synthesis of some sulfurated 1,2,3-triazole derivatives and the biological evaluation, for the superoxide dismutase-like activity, of these new compounds together with several 1,2,3-triazoles previously described by us. All the compounds possess a SOD-like activity and some of them showed an activity equivalent to or higher than those of penicillamine or thiopronin, which are well known therapeutic drugs in the treatment of rheumatoid arthritis.
本文报道了一些硫化1,2,3 - 三唑衍生物的合成，以及对这些新化合物与我们之前描述的几种1,2,3 - 三唑类化合物进行的超氧化物歧化酶样活性的生物学评价。所有化合物都具有超氧化物歧化酶样活性，其中一些化合物的活性与青霉胺或硫普罗宁相当或更高，青霉胺和硫普罗宁是治疗类风湿性关节炎的著名治疗药物。
