胆酸三聚体的合成及胶束模拟性质。
Synthesis and micellar mimic properties of bile acid trimers.
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
出版信息
Bioorg Med Chem Lett. 2013 Mar 1;23(5):1302-5. doi: 10.1016/j.bmcl.2012.12.102. Epub 2013 Jan 12.
Two fan-shaped bile acid trimers have been synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) 'click chemistry', and their extraction experiments of cresol red sodium (CR) and pyrene were investigated in the polar and non-polar solvents, respectively. The transmission electron microscopy (TEM) results showed that the homogenous hollow capsules formed with the diameter size range of 40-70 nm in a solution of water and acetone. Thus the amphiphilicity of fan-shaped bile acid trimers might be used as the promising candidate in biological and drug delivery applications.
已经通过 Cu（I）-催化的叠氮化物-炔烃环加成（CuAAC）“点击化学”合成了两种扇形胆酸三聚体，并分别在极性和非极性溶剂中研究了它们对甲酚红钠（CR）和芘的萃取实验。透射电子显微镜（TEM）结果表明，在水和丙酮的溶液中形成了直径为 40-70nm 的均匀空心胶囊。因此，扇形胆酸三聚体的两亲性可能可作为生物和药物传递应用中的有前途的候选物。
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