强效且选择性的塔里奎达生物等排物作为 P-糖蛋白成像的潜在 PET 放射性示踪剂。
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.
机构信息
Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'A. Moro', via Orabona, 4, 70125 Bari, Italy.
出版信息
Bioorg Med Chem Lett. 2013 Mar 1;23(5):1370-4. doi: 10.1016/j.bmcl.2012.12.084. Epub 2013 Jan 5.
PMID:23374872
Abstract
Compounds 8a-d have been designed as bioisosters of tariquidar for imaging P-gp expression and density by PET. The results displayed that compounds 8b and 8d could be considered potential P-gp/BCRP ligands suitable as (11)C and (18)F radiotracers, respectively.
摘要
化合物 8a-d 被设计为 tariquidar 的生物等排物，用于通过 PET 成像 P-gp 表达和密度。结果表明，化合物 8b 和 8d 可分别被视为潜在的 P-gp/BCRP 配体，适合作为 (11)C 和 (18)F 放射性示踪剂。
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