St. Mary's College of Maryland, 18952 East Fishers Road, St. Mary's City, MD 20686, USA.
J Clin Neurosci. 2013 Mar;20(3):476-7. doi: 10.1016/j.jocn.2012.09.010. Epub 2013 Jan 31.
Zebrafish exhibit a preference for dark areas and this behavior has been used to characterize anxiety. Their responses to light may also be modified by ethanol. Using high-speed video recordings, we demonstrated that untreated animals were relatively more active immediately after a bright-dim transition compared to animals exposed to low dose ethanol (2%). Additionally, ethanol-treated larvae were more prone to initiating behavioral responses following abrupt changes of light intensity. In conclusion, the larval zebrafish is an excellent model for investigating locomotory kinetics as well as drugs with anxiolytic properties. High-speed video recordings of behavioral responses in this species are indeed very promising for high-throughput screening.
斑马鱼喜欢黑暗区域，这种行为已被用于表征焦虑。它们对光的反应也可能被乙醇改变。使用高速视频记录，我们证明未经处理的动物在明亮-昏暗转换后立即比暴露于低剂量乙醇（2%）的动物更活跃。此外，乙醇处理的幼虫在光强度突然变化后更容易开始行为反应。总之，幼鱼斑马鱼是研究运动动力学以及具有抗焦虑特性的药物的极好模型。该物种行为反应的高速视频记录确实非常适合高通量筛选。
