Department of Otolaryngology, Division of Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Am J Otolaryngol. 2013 May-Jun;34(3):239-44. doi: 10.1016/j.amjoto.2012.11.007. Epub 2013 Feb 1.
Castleman disease is a rare lymphoproliferative disorder with two primary subtypes that vary in presentation and course. Unicentric Castleman disease (UCD) presents as a solitary mass, most commonly in the mediastinum, and rarely in the head and neck. In contrast to multicentric Castleman disease (MCD), which features peripheral lymphadenopathy and numerous systemic symptoms, UCD is not typically associated with generalized symptoms. Here, we present an unusual case of UCD presenting as a slowly expanding, isolated neck mass in a 29-year-old woman. This case demonstrates the distinguishing clinical, radiologic, and histologic findings unique to UCD, which is often misdiagnosed as lymphoma or other malignant process. These findings stand in contrast to those observed in MCD patients, and hence, offer insight into the practical aspects of diagnosis and management of Castleman disease in the head and neck.
血管滤泡性淋巴结增生症是一种罕见的淋巴组织增生性疾病，有两种主要亚型，其表现和病程不同。局灶型血管滤泡性淋巴结增生症（UCD）表现为孤立性肿块，最常见于纵隔，也很少见于头颈部。与多中心型血管滤泡性淋巴结增生症（MCD）不同，后者表现为外周淋巴结病和多种全身症状，UCD通常不伴有全身症状。在这里，我们报告了一例不常见的 UCD 病例，该病例表现为 29 岁女性缓慢生长的孤立性颈部肿块。该病例显示了 UCD 独特的临床、影像学和组织学表现，这通常被误诊为淋巴瘤或其他恶性过程。这些发现与 MCD 患者观察到的结果形成对比，因此为头颈部血管滤泡性淋巴结增生症的诊断和治疗的实际方面提供了深入了解。
