Texas A&M University - San Antonio, One University Way, San Antonio, TX 78224, United States.
Med Hypotheses. 2013 Apr;80(4):360-7. doi: 10.1016/j.mehy.2012.12.023. Epub 2013 Feb 1.
Alzheimer's disease is a complex disorder whose etiology is still controversial. It is proposed that vestibular loss may contribute to the onset of Alzheimer's disease, which initially involves degeneration of cholinergic systems in the posterior parietal-temporal, medial-temporal, and posterior-cingulate regions. A major projection to this system emanates from the semicircular canals of the vestibular labyrinth, with vestibular damage leading to severe degeneration of the medial-temporal region. The vestibular loss hypothesis is further supported by the vestibular symptoms found in Alzheimer's patients as well as in various diseases that are major risk factors for Alzheimer's disease.
阿尔茨海默病是一种复杂的疾病，其病因仍存在争议。有人提出，前庭功能丧失可能导致阿尔茨海默病的发生，而这种疾病最初涉及到后顶叶-颞叶、内侧颞叶和后扣带回区域的胆碱能系统退化。该系统的一个主要投射来自前庭迷路的半规管，前庭损伤导致内侧颞叶严重退化。阿尔茨海默病患者以及各种可能导致阿尔茨海默病的主要危险因素的疾病中发现的前庭症状进一步支持了前庭丧失假说。
