Bit1 在细胞失巢凋亡抵抗和肿瘤转移中的作用。
Bit1 in anoikis resistance and tumor metastasis.
机构信息
Department of Biology, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA.
出版信息
Cancer Lett. 2013 Jun 10;333(2):147-51. doi: 10.1016/j.canlet.2013.01.043. Epub 2013 Jan 31.
Abstract
Epithelial cells and most adherent normal cells rely on adhesion-dependent, integrin-mediated survival signals from the extracellular matrix (ECM) to survive. When these cells are deprived of adhesion to the ECM, they undergo a specific form of apoptosis termed "anoikis." In contrast, malignant cells have attained mechanisms to enable them to survive in the absence of adhesion and are considered anchorage-independent. This review will focus on the biological function of the Bcl2-inhibitor of transcription (Bit1) protein in the anoikis process, the underlying molecular mechanism of Bit1 apoptotic function, and its role in tumor metastasis.
摘要
上皮细胞和大多数贴壁正常细胞依赖于细胞外基质（ECM）提供的、黏附依赖性的整合素介导的存活信号来维持生存。当这些细胞失去与 ECM 的黏附时，它们会经历一种特定形式的凋亡，称为“失巢凋亡”。相比之下，恶性细胞已经获得了在没有黏附的情况下存活的机制，因此被认为是不依赖于锚定的。本综述将重点介绍 Bcl2 转录抑制剂（Bit1）蛋白在失巢凋亡过程中的生物学功能、Bit1 凋亡功能的潜在分子机制及其在肿瘤转移中的作用。
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本文引用的文献
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TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells.TLE1 是一种失巢凋亡调控因子，在乳腺癌细胞中被 Bit1 下调。
Mol Cancer Res. 2012 Nov;10(11):1482-95. doi: 10.1158/1541-7786.MCR-12-0144. Epub 2012 Sep 4.
2
Metastasis of tumor cells is enhanced by downregulation of Bit1.肿瘤细胞的转移能力会被 Bit1 的下调所增强。
PLoS One. 2011;6(8):e23840. doi: 10.1371/journal.pone.0023840. Epub 2011 Aug 23.
3
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J Biol Chem. 2011 Apr 22;286(16):14713-23. doi: 10.1074/jbc.M111.228387. Epub 2011 Mar 7.
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