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脑源性神经营养因子的中枢表达和厌食作用受循环雌二醇水平的调节。

Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels.

机构信息

Center for Physiology and Neuroscience, Department of Biology, Miami University, Oxford, OH, USA.

出版信息

Horm Behav. 2013 Mar;63(3):533-42. doi: 10.1016/j.yhbeh.2013.01.009. Epub 2013 Jan 31.

Abstract

Estrogens potently suppress food intake. Compelling evidence suggests that estradiol, the primary form of estrogens, reduces food intake by facilitating other anorectic signals. Brain-derived neurotrophic factor (BDNF), like estradiol, appears to suppress food intake by affecting meal size. We hypothesized that estradiol modulates Bdnf expression and the anorectic effect of BDNF. The first goal was to determine whether Bdnf expression was regulated by endogenous estradiol of cycling rats and by cyclic estradiol treatment using ovariectomized rats. Bdnf expression within the ventromedial nucleus of hypothalamus (VMH) was temporally elevated at estrus following the estradiol peak, which coincided with the decline in feeding at this phase of the ovarian cycle. Additionally, food intake and body weight were increased following ovariectomy with a parallel decrease in Bdnf expression in the VMH. All of these alterations were reversed by cyclic estradiol treatment, suggesting that Bdnf expression within the VMH was regulated in an estradiol-dependent manner. The second goal was to determine whether estradiol modulates the anorectic effect of BDNF. Sham-operated estrous rats and ovariectomized rats cyclically treated with estradiol responded to a lower dose of central administration of BDNF to decrease food intake than male rats and oil-treated ovariectomized rats, implying that endogenous estradiol or cyclic estradiol replacement increased the sensitivity to anorectic effect of BDNF. These data indicate that Bdnf expression within the VMH and the anorectic effect of BDNF varied depending on plasma estradiol levels, suggesting that estradiol may regulate BDNF signaling to regulate feeding.

摘要

雌激素能有效抑制食欲。大量证据表明,雌激素的主要形式——雌二醇,通过促进其他厌食信号来减少食物摄入。脑源性神经营养因子(BDNF)与雌二醇一样,似乎通过影响进食量来抑制食欲。我们假设雌二醇调节 Bdnf 表达和 BDNF 的厌食作用。第一个目标是确定内源性雌二醇循环大鼠和去卵巢大鼠用循环雌二醇处理是否调节 Bdnf 表达。下丘脑腹内侧核(VMH)内的 Bdnf 表达在发情期雌二醇峰值后呈时间性升高,这与卵巢周期此阶段进食减少相吻合。此外,去卵巢后,食物摄入和体重增加,同时 VMH 中的 Bdnf 表达减少。所有这些变化都被循环雌二醇治疗逆转,表明 VMH 内的 Bdnf 表达受雌二醇的调节。第二个目标是确定雌二醇是否调节 BDNF 的厌食作用。假手术发情期大鼠和用雌二醇循环处理的去卵巢大鼠对中央给予较低剂量 BDNF 以减少食物摄入的反应优于雄性大鼠和油处理的去卵巢大鼠,这表明内源性雌二醇或循环雌二醇替代增加了对 BDNF 厌食作用的敏感性。这些数据表明,VMH 内的 Bdnf 表达和 BDNF 的厌食作用随血浆雌二醇水平而变化,表明雌二醇可能调节 BDNF 信号转导以调节进食。

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