Ziemka-Nałęcz Malgorzata, Zalewska Teresa
NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Acta Neurobiol Exp (Wars). 2012;72(4):309-24. doi: 10.55782/ane-2012-1904.
The discovery of neurogenic response subsequent to brain injuries has led to the hypothesis that the expansion of the pool of endogenous progenitors could augment the regenerative capacity of the damaged areas. However, it occurred that endogenous spontaneous neurogenesis is insufficient for replacing the lost neurons and to achieve global repair, particularly in aging brain. Until today, a great effort has been made attempting to promote "reactive neurogenesis" more successful. It was found that small chemical molecules exert stimulation of neurogenesis and probably might help to induce neuronal endogenous cell replacement in various neurological diseases. In this review we briefly highlight the current data regarding effect of brain ischemia and age-related neurodegenerative diseases on neural stem cells in situ and potential therapeutic effect of their stimulation.
脑损伤后神经源性反应的发现引发了一种假说，即内源性祖细胞库的扩大可能会增强受损区域的再生能力。然而，事实证明内源性自发神经发生不足以替代丢失的神经元并实现全面修复，尤其是在衰老大脑中。直到如今，人们付出了巨大努力试图更成功地促进“反应性神经发生”。研究发现，小分子可刺激神经发生，可能有助于在各种神经疾病中诱导神经元内源性细胞替代。在本综述中，我们简要强调了有关脑缺血和年龄相关性神经退行性疾病对原位神经干细胞的影响及其刺激的潜在治疗效果的当前数据。
