Lok E, Scott F W, Mongeau R, Nera E A, Malcolm S, Clayson D B
Toxicology Research Division, Health and Welfare Canada, Banting Research Centre, Ottawa, Ontario.
Cancer Lett. 1990 May 15;51(1):67-73. doi: 10.1016/0304-3835(90)90232-m.
Two experiments have been conducted to determine the effects of calorie restriction on cellular proliferation in female mouse tissues. In the first experiment, 25% calorie restriction led to a decrease in cellular proliferation, measured by the [3H]thymidine labeling index, in each of the 7 tissues examined. The duct lining cells of the mammary gland were the most affected. This conclusion was confirmed in the second experiment in which levels of 0, 10, 20, 30 and 40% calorie restriction were employed. The difference in response of the duct cells of the mammary gland and the crypt cells of the colo-rectum is discussed in light of the opinion that the formation of cancer of these tissues in humans may be markedly affected by diet.
已经进行了两项实验来确定热量限制对雌性小鼠组织中细胞增殖的影响。在第一个实验中，25%的热量限制导致通过[3H]胸苷标记指数测量的所检查的7种组织中的每一种组织的细胞增殖减少。乳腺导管内衬细胞受影响最大。这一结论在第二个实验中得到了证实，在该实验中采用了0%、10%、20%、30%和40%的热量限制水平。根据饮食可能会显著影响人类这些组织癌症形成的观点，讨论了乳腺导管细胞和结肠直肠隐窝细胞反应的差异。
