Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, Universite Paris-Sud, Clamart, France.
Fertil Steril. 2013 Apr;99(5):1182-8. doi: 10.1016/j.fertnstert.2013.01.090. Epub 2013 Feb 4.
Retrieval of immature oocytes from unstimulated ovaries, followed by in vitro maturation (IVM) was initially proposed to avoid the risks and side effects of exogenous gonadotropin administration. Therefore, during the past decades, IVM was mainly offered to patients with polycystic ovary syndrome (PCOS) at high risk of ovarian hyperstimulation syndrome (OHSS). However, the development of fertility preservation has recently opened new perspectives in the field of IVM. The present review summarizes uncommon indications of IVM, which is a viable option to treat infertility in patients with ovarian resistance to FSH, but may also be considered to preserve fertility in leukemia as well as before ovarian transposition and endometrioma excision.
从未受刺激的卵巢中取出未成熟卵母细胞，然后进行体外成熟（IVM）最初是为了避免外源性促性腺激素给药的风险和副作用。因此，在过去的几十年中，IVM 主要提供给患有多囊卵巢综合征（PCOS）且有发生卵巢过度刺激综合征（OHSS）高风险的患者。然而，生育力保存的发展最近为 IVM 领域开辟了新的视角。本综述总结了 IVM 的非常见适应证，这是治疗对 FSH 有卵巢抵抗的患者不孕的可行选择，但也可考虑在白血病、卵巢移位和子宫内膜异位瘤切除之前保留生育力。
