Department of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Am J Perinatol. 2013 Nov;30(10):863-70. doi: 10.1055/s-0033-1333669. Epub 2013 Feb 4.
To examine the effects of biological maternal sounds (BMS) on weight gain velocity in very low-birth-weight (VLBW) infants (≤ 1,500 g).
An exploratory study with a matched-control design. A prospective cohort of VLBW infants exposed to attenuated recordings of BMS during their neonatal intensive care unit hospitalization were compared with retrospective controls matched 1:1 for sex, birth weight, gestational age, scores for neonatal acute physiology and perinatal extension (SNAPPE - II) scores (n = 32).
A linear mixed model controlling for gestational age, chronic lung disease, and days to regain birth weight revealed that infants receiving BMS significantly improved their weight gain velocity compared matched controls (p < 0.001) during the neonatal period. No differences were found on days spent nothing by mouth (p = 0.18), days until full enteral feeds (p = 0.51), total fluid intake (p = 0.93), or caloric intake (p = 0.73).
Exposure to BMS may improve weight gain velocity in VLBW infants. Further research is needed to evaluate the effectiveness of this noninvasive intervention during the neonatal period.
研究生物母体声音（BMS）对极低出生体重（VLBW）婴儿（≤1500 克）体重增长速度的影响。
采用匹配对照设计的探索性研究。将在新生儿重症监护病房住院期间接受衰减 BMS 记录的 VLBW 婴儿与性别、出生体重、胎龄、新生儿急性生理学和围产期扩展评分（SNAPPE-II）评分相匹配的回顾性对照进行比较（n=32）。
通过控制胎龄、慢性肺病和恢复出生体重的天数，线性混合模型显示，接受 BMS 的婴儿在新生儿期的体重增长速度明显快于匹配对照组（p<0.001）。在无口喂养天数（p=0.18）、完全肠内喂养天数（p=0.51）、总液体摄入量（p=0.93）或热量摄入量（p=0.73）方面无差异。
暴露于 BMS 可能会提高 VLBW 婴儿的体重增长速度。需要进一步研究来评估这种非侵入性干预措施在新生儿期的有效性。
