Funata M, Tokoro T
Department of Ophthalmology, Tokyo Medical and Dental University, Japan.
Graefes Arch Clin Exp Ophthalmol. 1990;228(2):174-9. doi: 10.1007/BF00935729.
To elucidate changes in the sclera of myopic eyes free of other obvious pathological features, morphometric and ultrastructural studies on the posterior sclera at the foveola of the three lid-fused monkeys that had developed high myopia were performed. The myopic eyes showed increased axial length, and their scleral thickness was about half that of the control eyes. Furthermore, a gradual increase in the size of collagen bundles and fibrils from the inner to the outer layer of the sclera was observed in the control eyes, but was not evident in the myopic eyes. From the present study, it can be speculated that an alteration of fibrillogenesis in the sclera is a key feature of scleral thinning in lid-suture myopia, and that axial elongation of the eyeball results from a combination of altered fibrillogenesis and mechanical expansion.
为阐明无其他明显病理特征的近视眼巩膜的变化，对三只已发展为高度近视的睑融合猴的黄斑中心凹处的后巩膜进行了形态计量学和超微结构研究。近视眼的眼轴长度增加，其巩膜厚度约为对照眼的一半。此外，在对照眼中观察到巩膜从内层到外层的胶原束和纤维大小逐渐增加，但在近视眼中不明显。从本研究可以推测，巩膜中纤维形成的改变是睑缝合性近视中巩膜变薄的关键特征，而眼球的轴向伸长是纤维形成改变和机械扩张共同作用的结果。
