Department of Gastroenterologic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, 2) Department of General Surgery, Daqing Oilfield General Hospital, Daqing, Heilongjiang Province,China.
PLoS One. 2013;8(1):e54502. doi: 10.1371/journal.pone.0054502. Epub 2013 Jan 30.
The prognostic significance of tumor size in gastric cancer is not well defined. The objective of this study was to identify the prognostic value of tumor size in patients with gastric cancer.
We retrospectively reviewed a total of 1800 patients with gastric cancer admitted to our hospital between 1997 and 2007. These patients were divided into two groups according to tumor size: small size group (SSG, tumor ≤5 cm) and large size group (LSG, tumor >5 cm). We compared clinico-pathologic features of the two groups and investigated the prognostic factors by performing univariate, multivariate, and stage- stratified analyses according to tumor size.
LSG had more aggressive clinico-pathologic features than SSG. Tumor size was an independent prognostic indicator in patients with gastric cancer. In a stratified-pT, pN, and pTNM analysis, survival of patients with LSG was significantly worse than that of patients with SSG and advanced stage. Tumor size was not a significant predictor of survival in patients with early stage tumors. Large tumor size was associated with shorter survival in patients with stages N0, N1, N2, and N3, and stages I, II, III, and IV.
Tumor size is a simple and practical prognostic factor in patients with gastric cancer. Tumor size could supplement clinical staging in the future.
肿瘤大小在胃癌中的预后意义尚未明确。本研究旨在确定肿瘤大小对胃癌患者的预后价值。
我们回顾性分析了 1997 年至 2007 年间我院收治的 1800 例胃癌患者。根据肿瘤大小将这些患者分为两组：小肿瘤组（SSG，肿瘤≤5cm）和大肿瘤组（LSG，肿瘤>5cm）。我们比较了两组的临床病理特征，并根据肿瘤大小进行单因素、多因素和分期分层分析，探讨预后因素。
LSG 具有更具侵袭性的临床病理特征。肿瘤大小是胃癌患者的独立预后指标。在分层的 pT、pN 和 pTNM 分析中，LSG 患者的生存明显差于 SSG 患者和晚期患者。肿瘤大小不是早期肿瘤患者生存的显著预测因素。大肿瘤大小与 N0、N1、N2 和 N3 期以及 I、II、III 和 IV 期患者的较短生存期相关。
肿瘤大小是胃癌患者的一个简单实用的预后因素。肿瘤大小未来可能会补充临床分期。
