Kim Dong Yi, Joo Jae Kyoon, Park Young Kyu, Ryu Seong Yeob, Kim Young Jin, Kim Shin Kon
Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, 8, Hakdong, Dongku, Gwangju, 501-757, South Korea.
Langenbecks Arch Surg. 2007 Mar;392(2):131-4. doi: 10.1007/s00423-006-0114-9. Epub 2006 Nov 7.
We analyzed the clinicopathologic features of node-positive gastric carcinoma patients who were long-term survivors (5 years or longer) and evaluated the predictive factors associated with long-term survival.
Of 554 node-positive gastric carcinoma patients with curative resection, 161 (29.1%) were long-term survivors, and 393 died of the disease before 5 years.
The long-term survivor group had a recurrence rate of 16.1%, while the recurrence rate was 95.4% in the short-term survivor group (P < 0.05). The mean tumor size in the long-term survivors (4.5 cm) was significantly smaller than that in the short-term survivors (5.3 cm; P < 0.001). A depth of invasion greater than T3 was found more frequently in the short-term survivor group (88.1%) than in the long-term survivor group (70.1%; P < 0.001). Using Cox's proportional hazard regression model, the only factor found to be an independent, statistically significant prognostic parameter was tumor size (risk ratio, 0.301; 95% confidence interval, 0.10-0.88; P < 0.05).
The tumor size emerged as the only independent, significant factor for the prediction of long-term survival in node-positive gastric carcinoma patients with curative resection.
我们分析了长期生存（5年或更长时间）的淋巴结阳性胃癌患者的临床病理特征，并评估了与长期生存相关的预测因素。
在554例行根治性切除的淋巴结阳性胃癌患者中，161例（29.1%）为长期生存者，393例在5年内死于该疾病。
长期生存组的复发率为16.1%，而短期生存组的复发率为95.4%（P<0.05）。长期生存者的平均肿瘤大小（4.5cm）显著小于短期生存者（5.3cm；P<0.001）。短期生存组（88.1%）中浸润深度大于T3的情况比长期生存组（70.1%）更常见（P<0.001）。使用Cox比例风险回归模型，发现唯一具有统计学意义的独立预后参数是肿瘤大小（风险比，0.301；95%置信区间，0.10 - 0.88；P<0.05）。
肿瘤大小是预测行根治性切除的淋巴结阳性胃癌患者长期生存的唯一独立显著因素。
