Departments of Psychiatry and Neuroscience, Columbia University, New York, NY 10032, USA.
Curr Opin Neurobiol. 2013 Jun;23(3):399-406. doi: 10.1016/j.conb.2013.01.011. Epub 2013 Feb 4.
Serotonin (5-hydroxytryptamine; 5-HT) is an ancient signaling molecule that has a conserved role in modulating mood and behavior. Integral to its pleiotropic actions is the existence of multiple receptors, expressed in distinct but often overlapping patterns within the brain and the periphery. The existence of ∼14 mammalian receptor subtypes, many of which possess similar pharmacological profiles, has made assigning functional roles for these receptors challenging. This challenge has been further compounded by the revelation that a single receptor can have several different functions depending upon where and when it is expressed and activated, that is, in brain versus periphery, or at different developmental time points. This review highlights the contribution of genetic techniques to dissect the specific function of distinct serotonin receptor populations across the life course, with an emphasis on the contribution of different serotonin 1A receptor populations to mood and behavior. Similar approaches hold the promise to elucidate the functional roles of other receptors, as well as the interaction of serotonin with other neuroendocrine modulators of mood and behavior.
血清素（5-羟色胺；5-HT）是一种古老的信号分子，在调节情绪和行为方面具有保守作用。其多种作用的基础是存在多种受体，这些受体在大脑和外周组织中以不同但常常重叠的模式表达。在哺乳动物中存在约 14 种受体亚型，其中许多具有相似的药理学特征，这使得为这些受体分配功能角色具有挑战性。这种挑战因发现单一受体可以根据其表达和激活的位置和时间（即大脑与外周、或不同的发育时间点）具有几种不同的功能而进一步加剧。本综述强调了遗传技术在解析整个生命过程中不同血清素受体群体的特定功能方面的贡献，重点介绍了不同 5-羟色胺 1A 受体群体对情绪和行为的贡献。类似的方法有望阐明其他受体的功能作用，以及血清素与其他调节情绪和行为的神经内分泌调节剂的相互作用。
