Jennekens-Schinkel A, Lanser J B, van der Velde E A, Sanders E A
Neuropsychology Section, State University Leiden, The Netherlands.
J Neurol Sci. 1990 Jan;95(1):89-103. doi: 10.1016/0022-510x(90)90119-8.
In a group of 39 multiple sclerosis (MS) patients with at least average intelligence quotients (IQ), performances were examined in tests requiring language usage and figure copying. Numbers of correct, digressive and erroneous responses were analysed and compared with those obtained in 24 healthy volunteers, matched to the patients group for socio-economic status. The examined specific tasks yielded no additional contribution to the prevalence estimation of cognitive deterioration (18%), as based on an assessment of general intelligence. Linguistic or cognitive-constructional problems were no more severe or more frequent in MS patients than those in control subjects. Upon writing or copying figures, pencil stroke and pencil pressure were deficient. Speed of reading aloud and of colour naming was decreased in the MS group, the most probable explanation being impaired control of the phonatory apparatus, oculomotor problems or weakness of colour vision. Decreases in speed of performance are not necessarily of cognitive origin. Differences between the present and previous reports based on similar tasks, appear to be connected partly with differences in patient selection. Of the present group, all MS patients were in quiescent disease stages, depression was mild or absent and physical handicap was less than in most studies reporting definite specific deficits.
在一组39名至少具有平均智商(IQ)的多发性硬化症(MS)患者中,对其在需要语言运用和图形临摹的测试中的表现进行了检查。分析了正确、离题和错误反应的数量,并与24名健康志愿者(在社会经济地位方面与患者组相匹配)的相应数量进行了比较。基于一般智力评估,所检查的特定任务对认知衰退患病率估计值(18%)没有额外贡献。MS患者的语言或认知构建问题并不比对照组更严重或更频繁。在书写或临摹图形时,笔触和笔压存在缺陷。MS组大声朗读和颜色命名的速度降低,最可能的解释是发声器官控制受损、动眼问题或色觉减弱。表现速度的降低不一定源于认知问题。基于类似任务的当前报告与先前报告之间的差异,似乎部分与患者选择的差异有关。在当前这组患者中,所有MS患者均处于疾病静止期,抑郁症状轻微或无抑郁症状,身体残疾程度低于大多数报告明确特定缺陷的研究。