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多发性硬化病史后对认知障碍的关注或忽视

Focus or Neglect on Cognitive Impairment Following the History of Multiple Sclerosis.

作者信息

Nocentini Ugo

机构信息

Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy;

Istituto di Ricovero e Cura a Carattere Scientifico "Santa Lucia" Foundation, 00179 Rome, Italy.

出版信息

NeuroSci. 2023 Feb 15;4(1):0. doi: 10.3390/neurosci4010008. eCollection 2023 Mar.

Abstract

Cognitive disorders are now considered an integral part of the picture of multiple sclerosis. If we trace the history of the accounts of this disease, from the early descriptions by Jean-Martin Charcot, the first to provide systematic characteristics of multiple sclerosis, to present-day accounts, reports of cognitive disturbances have demonstrated an alternating trend. Cognitive disturbances were identified in the beginning, quite clearly for the times. Then, for a long time, they were considered infrequent or attributed to other factors. Finally, since the 1980s, cognitive disturbances have been the subject of increasingly in-depth studies, and are currently assumed to be a very important consequence of multiple sclerosis. In this work, the history of the description of cognitive disorders of multiple sclerosis will be retraced by analyzing the possible reasons for the differences in attention they have received over time. It emerged from the analysis that, as in the case of other pathologies, various factors have influenced how cognitive disorders have been taken into consideration. Some of these factors are inherent to the very nature of the cognitive impairments present in multiple sclerosis; others are linked to historical periods, or to the different ways of approaching the analysis of the phenomena caused by a disease. The reflections made on these topics should, among other things, increase our awareness of how scientific investigation is invariably placed in the historical context in which it is carried out.

摘要

认知障碍现在被认为是多发性硬化症症状的一个组成部分。如果我们追溯这种疾病的记载历史,从让 - 马丁·夏科最早对多发性硬化症进行系统描述,到如今的相关记载,关于认知障碍的报告呈现出一种交替趋势。一开始,认知障碍就被明确识别出来,在当时算是相当清晰的了。然后,在很长一段时间里,它们被认为不常见,或者被归因于其他因素。最后,自20世纪80年代以来,认知障碍一直是越来越深入研究的主题,目前被认为是多发性硬化症的一个非常重要的后果。在这项工作中,将通过分析随着时间推移对认知障碍关注差异的可能原因,来追溯多发性硬化症认知障碍描述的历史。分析结果表明,与其他病症情况一样,多种因素影响了对认知障碍的考量方式。其中一些因素与多发性硬化症中存在的认知障碍的本质特性有关;其他因素则与历史时期,或者与分析疾病所引发现象的不同方法有关。对这些主题的思考,除其他方面外,应能增强我们对科学研究总是处于其开展的历史背景中的认识。

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